COVID-19 Coronavirus Research Tools
Pre-Made AAVs Center
Neuronal Tracing Tool

BrainVTA

Construction and Packaging Service of virus Vector

Construction and Packaging Services of AAV

Large scale AAV production

The tectonigral pathway regulates appetitive locomotion in pr
The viruses used in this article from BrainVTA are in the table below
AAVs  AAV-DJ
 AAV2-retro
Meizhu Huang, Dapeng Li, Xinyu Cheng, Qing Pei, Zhiyong Xie, Huating Gu, Xuerong Zhang, Zijun Chen, Aixue Liu, Yi Wang, Fangmiao Sun, Yulong Li, Jiayi Zhang, Miao He, Yuan Xie, Fan Zhang, Xiangbing Qi, Congping Shang, Peng Cao
Pub Date: 2021-07-20, DOI: 10.1038/s41467-021-24696-3, Email: [email protected]
Appetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior—predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice.

Figure 1. Schematic diagram showing fiber photometry recording from SNc-projecting SC neurons.
In the present study, the authors explored the role of SC–SNc pathway in appetitive locomotion during predatory hunting. They found that the SC–SNc pathway transmitted locomotion speed signals to SNc dopamine neurons and triggered dopamine release in the dorsal striatum. Activation of this pathway during predatory hunting increased the speed of appetitive locomotion, an effect that depended on the activities of SNc dopamine neurons. Conversely, synaptic inactivation of this pathway impaired appetitive locomotion without changing defensive locomotion. Together, these data revealed the SC as an important source to provide locomotion-related signals to SNc dopamine neurons to boost appetitive locomotion.
 
BrainVTA offers viral vector construction & virus packaging services for AAV, LV, RABV, PRV, HSV and VSV that help researchers explore questions about genes, neurons, circuitry structure, function of brain network, mechanism and treatment of diseases.
If you have any needs, just email us at [email protected].



50% discount for Pre-Made AAVs