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Oxytocin in the anterior cingulate cortex attenuates neuropat
AAV-ChR2 and AAV-eNpHR3.0 were used for optogenetic experiments. (From BrainVTA)
The viruses used in this article from BrainVTA are in the table below
Optogenetic  PT-0001 AAV-DIO-ChR2-EYFP
 PT-0017 AAV-DIO-eNpHR3.0-mCherry
Control  PT-0012 AAV-DIO-EYFP
Xu-Hui Li, Takanori Matsuura, Man Xue, Qi-Yu Chen, Ren-Hao Liu, Jing-Shan Lu, Wantong Shi, Kexin Fan, Zhaoxiang Zhou, Zhuang Miao, Jiale Yang, Sara Wei, Feng Wei, Tao Chen, Min Zhuo
Pub Date: 2021-07-21, DOI: 10.1016/j.celrep.2021.109411, Email: [email protected]
Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and post-LTP contribute to chronic-pain-related anxiety and behavioral sensitization. The roles of oxytocin in the ACC have not been studied. Here, we find that microinjections of oxytocin into the ACC attenuate nociceptive responses and anxiety-like behavioral responses in animals with neuropathic pain. Application of oxytocin selectively blocks the maintenance of pre-LTP but not post-LTP. In addition, oxytocin enhances inhibitory transmission and excites ACC interneurons. Similar results are obtained by using selective optical stimulation of oxytocin-containing projecting terminals in the ACC in animals with neuropathic pain. Our results demonstrate that oxytocin acts on central synapses and reduces chronic-pain-induced anxiety by reducing pre-LTP.
In this study, the authors report that microinjection of oxytocin into the ACC attenuates nerve-injury-induced nociceptive and anxiety behavioral responses. They show that oxytocin blocks the maintenance of pre-LTP and potentiates inhibitory transmission. Optical activation of endogenous oxytocin release in the ACC blocks pre-LTP and produces analgesic and anxiolytic effects.
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