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Whole-Brain Mapping of Projection from Mice Lateral Septal Nu
HSV -EGFP and PRV -EGFP viruses (From BrainVTA) were used for anterograde and retrograde tracing to investigated the neurocircuits of LS and identify the sequence of projections from the lateral septal nucleus.
The viruses used in this article from BrainVTA are in the table below
Herpes simplex virus 1 strain H129  H01001 HSV-EGFP
Pseudorabies virus strain Bartha  P01001 PRV-CMV-EGFP
Pub Date: 2019-07-02,  DOI:10.1242/bio.043554   Email:
Ke Deng, Lu Yang, Jing Xie, He Tang, Gui-Sheng Wu, Huai-Rong Luo
The lateral septal nucleus (LS) plays a critical role in emotionality, social behavior, and feeding processes, through neural connecting with hippocampus and hypothalamus. We investigated the neurocircuits of LS by herpes simplex virus 1 strain H129 (H129) and pseudorabies virus stain Bartha (PRV). Virus H129 indicates that LS directly project to some cerebral nuclei (nucleus accumbens, bed nuclei of the stria terminalis, amygdala), part of hypothalamus (median preoptic, paraventricular, dorsomedial nucleus, and lateral area) and thalamus (medial habenula, paraventricular nuclei, parataenial, reuniens, and the medial line nuclei), and the pontine central gray. Then the LS secondary project to CA3 and CA1 field of the hippocampal formation, lateral and medial preoptic area, and the mammillary body. PRV tracing shows that LS are mainly receiving primary inputs from the amygdala, hippocampus, hypothalamic, thalamus, midbrain and hindbrain, and secondary inputs from dorsal and central linear nucleus raphe, lateral part of the superior central nucleus raphe, also the ventral anterior-lateral complex, the intermediodorsal nucleus, the central medial nucleus, the rhomboid nucleus, and the submedial nucleus of the thalamus. The neurocircuits revealed here would help to understand and further research on the function of LS.

Fig.1 Overview of the projections from mice rostral part of lateral septal.
To determine the cascade of projection from the lateral septal nucleus, using anterograde trans-neuronal virus H129 and retrograde spreading virus PRV (From BrainVTA) tracing, the researchers identify the sequence of projections from the lateral septal nucleus and expand the data of the neurocircuits, that would help to understand brain function.

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